Northeast Missouri Vacation Packages

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Your Northeast Missouri Vacation

When you're ready for your next big adventure, our Northeast Missouri vacation packages are the answer. Dining and culture are among the many things that make this destination truly unforgettable. Kick off your trip to Northeast Missouri with some time exploring St. Louis visiting popular sights like Enterprise Centre and Busch Stadium. St. Charles is another top city that draws travellers from far and wide. Ameristar Casino St. Charles and Westport Plaza are two of the leading places to see in this destination. From the moment you book your Northeast Missouri vacation to when you get back home, Expedia will take care of you each step of the way.

Top Northeast Missouri Vacation Deals

Price found within the past 48 hours. Click for updated prices.
Capital O Amerihost Inn and Suites Mexico Hwy 54 MO

Capital O Amerihost Inn and Suites Mexico Hwy 54 MO

CA $884
per person
Oct 19 - Oct 25
found 23 hours ago
Roundtrip non-stop flight included
Toronto (YTO) to Columbia (COU)
5.6/10 (410 reviews)
The Wildwood Hotel

The Wildwood Hotel

CA $1,030
per person
Sep 25 - Sep 28
found 1 day ago
Roundtrip non-stop flight included
Toronto (YYZ) to St. Louis (STL)
9.2/10 Wonderful! (1,672 reviews)
Staff were so helpful and an initiating. Used this hotel as a stop over. I was pleasantly surprised.

Reviewed on Aug 10, 2026

The Cheshire

The Cheshire

CA $1,172
per person
Sep 25 - Sep 28
found 1 day ago
Roundtrip non-stop flight included
Toronto (YYZ) to St. Louis (STL)
8.8/10 Excellent! (1,006 reviews)
When checking in, the staff woman was less than friendly. There seemed to be a situation with another upset guest that may have caused the unpleasant nature. Once we entered the room, we noticed right away a musty smell. The AC did not seem to be working correctly. Though it never got hot, it also never got any cooler. The furniture had visible stains and a few of the pillow cases had staining as well. The pillows themselves are downed pillows and once you lay on them, they flatten out thin. We requested a few extra pillows that were supposed to be brought to our room which never arrived. We requested more towels which were also supposed to be brought to our room which also never arrived. Breakfast on morning one for us which was Sunday was great, however it was apparent that the fruit and pastries were being reused daily and by our check out morning on Tuesday they were no good. The pool area was decent. You have to reserve the canopy so it was unusable to us. Overall, our stay was okay. I wouldn’t say it was awful but I wouldn’t say it was great either. We don’t intend on staying in the future.

Reviewed on Aug 9, 2026

 The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis

Central West End
CA $1,453
per person
Sep 25 - Sep 28
found 1 day ago
Roundtrip non-stop flight included
Toronto (YYZ) to St. Louis (STL)
9/10 Wonderful! (1,015 reviews)
Beautiful hotel and great location.

Reviewed on Aug 10, 2026

Where to stay in Northeast Missouri

Find the best Northeast Missouri areas and neighborhoods for the activities you enjoy most. Learn more about Northeast Missouri
The illuminated Gateway Arch at night with a city skyline in the background.

Clayton

1 out of top 10 points of interest in this area

Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.

An ornate hall with arched ceilings and intricate patterns.

Downtown West

3 out of top 10 points of interest in this area

If you're spending some time in Downtown West, St. Louis Union Station and St. Louis Aquarium at Union Station are top sights worth seeing.

A street with parked cars, a building with a sign reading "Brennan's", and a tree in front.

Central West End

1 out of top 10 points of interest in this area

Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.

A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

A wooden bridge with metal trusses, surrounded by trees.

St. Charles Historic District

Discover a national historic district featuring over 100 buildings, including the First Missouri State Capitol and St. Charles Odd Fellows Hall, showcasing architectural styles like Greek Revival and Italianate.

Ready to book your vacation to Northeast Missouri?

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Northeast Missouri Hotel Deals

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
CA $128
CA $149 total
Aug 30 - Aug 31
includes taxes & fees
Clayton Plaza Hotel & Extended Stay
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

777 Casino Center Drive Maryland Heights MO
Fully refundableReserve now, pay when you stay
CA $139
CA $204 total
Sep 8 - Sep 9
includes taxes & fees
8.6/10 Excellent! (2,206 reviews)
"If you are going to be spending time at the casino then the hotel is a much better location."

Reviewed on Aug 10, 2026

Hollywood Casino & Hotel St. Louis
Renaissance St. Louis Airport Hotel

Renaissance St. Louis Airport Hotel

9801 Natural Bridge Road St. Louis MO
Fully refundableReserve now, pay when you stay
CA $155
CA $181 total
Aug 23 - Aug 24
includes taxes & fees
8.4/10 Very good! (1,141 reviews)
"Flashing light on smoke detector in room all night. Hard beds. Overall good stay. Indoor and outdoor pools were good."

Reviewed on Aug 10, 2026

Renaissance St. Louis Airport Hotel
See all 3,006 properties in Northeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Northeast Missouri attractions

A baseball stadium with a large crowd, a prominent arch structure, and various advertisements.
Photo by Carl Guttovz

Busch Stadium

9.4/10 (4,850 reviews)
Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's acclaimed art scene or attend a baseball game.
See properties
A bronze elephant sculpture with a pumpkin on its back, surrounded by greenery.
Photo by Jeff White

St. Louis Zoo

9.2/10 (4,367 reviews)
In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world.
See properties
A cityscape with a prominent statue in the center, surrounded by various buildings and a large stadium.

Enterprise Center

8.8/10 (1,597 reviews)
Catch an event at Enterprise Center during your trip to St. Louis. Experience the area's acclaimed art scene or attend a baseball game.
See properties
A cityscape with a prominent arch structure, various high-rise buildings, and a large government building.

Dome at America’s Center

8.4/10 (1,229 reviews)
Catch an event at Dome at America’s Center during your trip to St. Louis. Experience the area's acclaimed art scene and great live music.
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A modern building with large glass windows, surrounded by a garden with red and pink tulips and purple flowers.

Forest Park

9.2/10 (3,389 reviews)
Nature, history and cultural institutions come together in one of the United States’ largest urban parks, which buzzes with St. Louis’ dynamic community spirit.
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A tightrope walker balancing on a wire between buildings.

City Museum

9.0/10 (3,209 reviews)
This quirky children’s museum invites visitors to crawl through whales, climb into tree houses and whiz down three-story slides.
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A historic building with a large lawn, a flagpole with flags, and a clear blue sky.

St. Louis University

8.6/10 (526 reviews)
Explore the campus of St. Louis University as part of your travels around St. Louis. Wander around the area's picturesque gardens or experience its fascinating museums.
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America's Center Convention Complex

8.8/10 (306 reviews)
Learn about the events happening at America's Center Convention Complex during your trip to St. Louis. Experience the area's acclaimed theater scene and great live music.
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What to do in Northeast Missouri

LEGOLAND® Discovery Center Kansas City

LEGOLAND® Discovery Center Kansas City

CA $39
per adult
LEGOLAND® Discovery Center Kansas City
Be Bop and Beyond 18th and Vine Live Jazz and Walking Tour

Be Bop and Beyond 18th and Vine Live Jazz and Walking Tour

CA $49
per adult
Be Bop and Beyond 18th and Vine Live Jazz and Walking Tour
See all activities in Northeast Missouri

Frequently asked questions

How much does a Northeast Missouri vacation package cost?
Live it up in Northeast Missouri from as little as CA $884. Choose from a great selection of flights, hotels and rental cars to suit your travel style. You can score even more discounts when you add a few sightseeing activities to your vacation package.
How do I get a cheap travel package to Northeast Missouri?
Our Northeast Missouri vacation packages promise plenty of savings for the savvy explorer. For the best deal, simply bundle your flights, hotels and extras (including tours) into a handy package. But low prices are only the start of your next memorable adventure. Book with Expedia and you'll have more than 550 airlines and 1,000,000 hotel options around the globe to choose from. No matter your budget or style, there's a vacation package that's perfect for you.
Where should I stay in Northeast Missouri?
You'll love St. Louis. Popular attractions, like Busch Stadium and Gateway Arch, will keep you entertained in this happening city.
What are the top hotels in Northeast Missouri?
For properties in St. Louis with comfy beds and friendly service, you can't top Hyatt Regency St. Louis at The Arch and Clayton Plaza Hotel & Extended Stay. If you're swinging by Wright City as well, you can look forward to a wonderful night's sleep at Holiday Inn Express Warrenton, an IHG Hotel or Super 7 Inn.
How far in advance should I book my Northeast Missouri vacation?
While not all airlines advertise ticket prices early, you can usually look up international flights on Expedia up to 12 months in advance. This is the time you'll bag some incredible deals. If you're booking late, you could still be in luck. Low prices sometimes become available a few weeks prior to departure.
What does an Expedia Northeast Missouri travel package include?
That depends on what you're looking for. If you're traveling solo, you might decide to combine hotels and flights. Bringing the whole crew to Northeast Missouri? A travel package including rental cars, flights and hotels might suit you better. Expedia gives you the flexibility to customize your travel package.
What should I know before booking a Northeast Missouri travel package?
Discover deals that fit your budget with an Expedia package. Airfares, hotels, rental cars — we're a one-stop shop for all of them. You'll save loads just for bundling your bookings. Whether you're embarking on a snow and ski adventure or kicking back on a warm beach, your dream getaway is only clicks away.
Can I choose my airline with a Northeast Missouri Expedia vacation package?
With a vacation package, the choice is in your hands. Whether you're hoping to fly to Northeast Missouri in business or coach, simply choose from the available airline options. Expedia has access to over 550 partner airlines globally.
If I'm not able to travel, can I cancel my Northeast Missouri vacation package?
If your vacation plans in Northeast Missouri have been upended, it's comforting to know that it's possible to amend or cancel your booking. If your booking was made within the last 24 hours, you may be able to get a refund. If your booking is older than that, your hotel, airline or car rental company may impose a fee. To find out more, check our Customer Service Portal.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.